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Articles and Research

STEM CELL RESEARCH

There are thousands of peer reviewed scientific publications and articles regarding the use of Stem Cells and their effectiveness in treating a wide range of conditions. As the field of Regenerative Medicine experiences significant growth more and more research and clinical studies support the use of Stem Cells and Stem Cell derived Exosomes.

Below are a collection of links to studies and articles about the use of Stem Cells.

Why Exosomes over Stem Cells

Many scientists now believe Exosomes are the next evolution in Stem Cell technology,” Dr. Ronald Klatz, President of the American Academy of Anti-Aging and Regenerative Medicine . You may be noticing there is a bunch of hype about Exosomes…

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases.

Background: Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for a reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage III and IV (eGFR 12-60 mg.ml) have been divided into two groups; twenty patients as treatment…

The Exosome Revolution in Regenerative Medicine: Amniotic fluid (AF) has taken the regenerative medicine world by storm over the last decade.

Amniotic fluid (AF) has taken the regenerative medicine world by storm over the last decade. It contains a substantial number of growth factors and immune components that provide benefits to a myriad of patients for regenerative purposes…

Mesenchymal stem cells derived Exosomes and microparticles protect cartilage and bone from degradation in Osteoarthritis.

Mesenchymal stem or stromal cells (MSCs) exert chondroprotective effects in preclinical models of osteoarthritis (OA). Most of their therapeutic effects are mediated via soluble mediators, which can be conveyed within extracellular vesicles (EVs)…

Intravenously delivered mesenchymal Stem Cell-derived Exosomes target M2-type macrophages in the injured spinal cord.

In a previous report we showed that intravenous infusion of bone marrow-derived mesenchymal stem calls (MSCs) improved functional recovery after contusive spinal cord injury (SCI) in the non-immunosuppressed rat, although the MSCs themselves were not detected at the spinal cord…

Exosomes, your body's answer to immune health. Mesenchymal stromal cells (MSC) have a profound effect on the regulation of the immune system.

Mesenchymal stromal cells (MSC) have a profound effect on the regulation of the immune system. MSCs show low expression of major histocompatibility complex (MHC)-II and costimulatory surface molecules that include…

Effects of Intrathecal Injection of the Conditioned Medium from Bone Marrow Stromal Cells on Spinal Cord Injury in Rats.

Bone marrow stromal cells (BMSCs) have been studied for the treatment of spinal cord injury (SCI). In previous studies, we showed that the transplantation of BMSCs, even though they disappeared from the host spinal cord within 1-3 weeks after transplantation, improved…

Exosomes as potential alternatives to Stem Cell therapy for intervertebral disc degeneration. In-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells.

Background: The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells such as nucleus pulposus cells (NPCs), remain unknown…

Stem cell paracrine actions and tissue regeneration Stem cells have emerged as a key element of regenerative medicine, providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries.

Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries…

Efficient expansion of mesenchymal stromal cells from umbilical cord under low serum conditions. would be attractive as a non-invasive source for cellular therapies.

Mesenchymal stromal cells (MSC) are of clinical interest for their potential use in regenerative medicine and immunotherapy. Originally derived from bone marrow (BM), MSC have now been isolated from most tissues, including umbilical cord (UC) and UC blood (UCB)….

Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility. Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs).

Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs). Apart from their prominent advantages, such as a painless collection procedure and faster self-renewal, UC-MSCs have shown the ability to…..

Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study.

In our present single-center pilot study, umbilical cord (UC)-derived mesenchymal stem cells (MSCs) had a good safety profile and therapeutic effect in severe and refractory systemic lupus erythematosus (SLE)…

Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience.

Mesenchymal stem cells (MSCs) are multi-potential nonhematopoietic progenitors and are capable of differentiating into several tissues of mesenchymal origin. We have shown that bone marrow-derived MSCs from both SLE patients and lupus-prone MRL/lpr mice…

Intra-articular injection of mesenchymal Stem Cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.

Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation. For the treatment of generalized cartilage loss in osteoarthritis…

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